Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity.

@article{Alpr2003ExpressionOC,
  title={Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity.},
  author={Al{\'a}n Alp{\'a}r and Kirstin Palm and Andreas Schierwagen and Thomas Arendt and Ulrich G{\"a}rtner},
  journal={The Journal of comparative neurology},
  year={2003},
  volume={467 1},
  pages={119-33}
}
The small G protein p21Ras is a critical molecular switch for relaying neurotrophic actions and is essential for normal functioning and plasticity of the nervous system. In this study, the morphogenetic effects of p21Ras were investigated on neurons in vivo. Morphological changes of layers II/III and Vb commissural pyramidal neurons of the primary somatosensory cortex were analyzed in transgenic mice expressing permanently active p21H-RasVal12 in postmitotic neurons. Pyramidal cells were… CONTINUE READING

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