Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replication.

@article{Baldeon2001ExpressionOC,
  title={Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replication.},
  author={Maria E Baldeon and Brian P. Ceresa and James E. Casanova},
  journal={Cellular microbiology},
  year={2001},
  volume={3 7},
  pages={473-86}
}
The enteric bacterial pathogen Salmonella typhimurium enters and proliferates within both phagocytic and non-phagocytic host cells. Upon entry, the bacteria reside in membrane-bound vacuoles (SCVs) that mature with time, as evidenced by the sequential loss of early endosomal markers, followed by the selective recruitment of a number of lysosomal membrane glycoproteins (LAMPs). This remodelling process renders the SCVs non-fusogenic with lysosomes and is also thought to create a vacuolar… CONTINUE READING

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