Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response.

@article{Fang1998ExpressionOC,
  title={Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response.},
  author={Yuan Fang and Chunfang Xu and Yang Xin Fu and V. Michael Holers and H{\'e}ctor R Molina},
  journal={Journal of immunology},
  year={1998},
  volume={160 11},
  pages={5273-9}
}
Two mechanisms could account for the impaired humoral immune response found in Cr2-/- mice. The absence of complement receptors 1 and 2 (CR1, CR2) on B cells could affect their activation. Alternatively, impaired Ag trapping by follicular dendritic cells (FDC) could affect B cell maturation into Ig-secreting or memory B cells. To compare the roles of CR1 and CR2 on B cells vs FDC in this abnormal response, bone marrow (BM) chimeric mice were generated and immunized with specific T-dependent Ags… CONTINUE READING
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