Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer

  title={Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer},
  author={Ayman Elnemr and Yutaka Yonemura and Etsurou Bandou and Kazuo Kinoshita and Taiichi Kawamura and Shigeru Takahashi and Shizuka Tochiori and Yoshio Endou and Takuma Sasaki},
  journal={Gastric Cancer},
Background: Collagenase-3 (matrix metalloproteinase-13; MMP-13) is a recently identified member of the matrix metalloproteinases (MMPs) with broad substrate specificity, and a potential role in tumor metastasis and invasion has been proposed for this enzyme. To date, in gastrointestinal tract tumors, collagenase-3 expression has been reported only in esophageal carcinoma; the presence and possible implications of this enzyme in the progression of gastric cancer are unknown. Methods: In this… CONTINUE READING