Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles.

@article{James2007ExpressionOC,
  title={Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles.},
  author={Francine O James and Diane B. Boivin and Sylvain Charbonneau and Val{\'e}rie B{\'e}langer and Nicolas Cermakian},
  journal={Chronobiology international},
  year={2007},
  volume={24 6},
  pages={1009-34}
}
The rhythmic expression of circadian clock genes in the neurons of the suprachiasmatic nucleus (SCN) underlies the manifestation of endogenous circadian rhythmicity in behavior and physiology. Recent evidence demonstrating rhythmic clock gene expression in non-SCN tissues suggests that functional clocks exist outside the central circadian pacemaker of the brain. In this investigation, the nature of an oscillator in peripheral blood mononuclear cells (PBMCs) is evaluated by assessing clock gene… CONTINUE READING
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