Expression of cln3 in Human NT2 Neuronal Precursor Cells and Neonatal Rat Brain

@article{Pane1999ExpressionOC,
  title={Expression of cln3 in Human NT2 Neuronal Precursor Cells and Neonatal Rat Brain},
  author={Maria A Pane and Kasturi Lahiri Puranam and Rose-Mary N. Boustany},
  journal={Pediatric Research},
  year={1999},
  volume={46},
  pages={367-367}
}
During brain development, excess neurons that are formed die by apoptosis. cln3 was recently identified as the gene defective in juvenile Batten disease, an inherited neurodegenerative disease of childhood. In this disease, neurons die by apoptosis. Overexpression of this gene increases survival of human NT2 neuronal precursor cells. We, therefore, hypothesized that cln3 may be present in developing neurons and may play an important role in regulating the developmental process. NT2 neuronal… CONTINUE READING

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