Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.

@article{Tanigawa2007ExpressionOC,
  title={Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.},
  author={Hiroyuki Tanigawa and Jeffrey T. Billheimer and Jun-ichiro Tohyama and Yuzhen Zhang and George H. Rothblat and Daniel J. Rader},
  journal={Circulation},
  year={2007},
  volume={116 11},
  pages={1267-73}
}
BACKGROUND Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apolipoprotein (apo) B-containing lipoproteins and in humans plays an important role in lipoprotein metabolism. However, the role that CETP plays in mediation of reverse cholesterol transport (RCT) remains unclear. We used a validated in vivo assay of macrophage RCT to test the effect of CETP expression in mice (which naturally lack CETP) on macrophage RCT, including in mice that… CONTINUE READING

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Mechanisms of Disease: HDL metabolism as a target for novel therapies

Nature Clinical Practice Cardiovascular Medicine • 2007

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