Expression of cholera toxin B subunit and assembly as functional oligomers in silkworm.

@article{Gong2005ExpressionOC,
  title={Expression of cholera toxin B subunit and assembly as functional oligomers in silkworm.},
  author={Zhao-hui Gong and H Jin and Yongfeng Jin and Yao-Zhou Zhang},
  journal={Journal of biochemistry and molecular biology},
  year={2005},
  volume={38 6},
  pages={717-24}
}
The nontoxic B subunit of cholera toxin (CTB) can significantly increase the ability of proteins to induce immunological tolerance after oral administration, when it was conjugated to various proteins. Recombinant CTB offers great potential for treatment of autoimmune disease. Here we firstly investigated the feasibility of silkworm baculovirus expression vector system for the cost-effective production of CTB under the control of a strong polyhedrin promoter. Higher expression was achieved via… CONTINUE READING
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