Expression of chimeric estrogen-glucocorticoid-receptor in the amygdala reduces anxiety

@article{Mitra2010ExpressionOC,
  title={Expression of chimeric estrogen-glucocorticoid-receptor in the amygdala reduces anxiety},
  author={Rupshi Mitra and Robert Morris Sapolsky},
  journal={Brain Research},
  year={2010},
  volume={1342},
  pages={33-38}
}
The basolateral amygdala is critical for generating anxiety, and exposure to glucocorticoids induces anxiety. The demonstrated ability of glucocorticoids to cause dendritic expansion and increase excitability in the amygdala could help mediate the behavioral effects of glucocorticoids, and thus may be important therapeutic target for anxiety. In contrast, estrogen has the opposite effects of glucocorticoids in many domains. In this study, we employed a gene therapeutic approach to reduce… 
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Neuronal Plasticity in the Amygdala Following Predator Stress Exposure
  • R. Mitra
  • Medicine, Biology
    Front. Behav. Neurosci.
  • 2019
TLDR
The role of basolateral amygdala (BLA) neurons in the mediation of non-consumptive effects of predation is reviewed to suggest that BLA is involved in creating anticipatory defensive behavior in response to the expectation of change in the environment.
Proteção conferida pelo enriquecimento ambiental na ansiedade induzida por estresse: a importância da sinalização via GR, ERK e CREB no complexo amigdalóide basolateral de ratos.
Novaes LS. Protection conferred by environmental enrichment on stress-induced anxiety: the importance of GR, ERK, and CREB pathways in the rat basolateral amygdala. [Masters thesis (Pharmacology)].
ACQUISITION OF FREEZING RESPONSE IN RATS: SEX DIFFERENCES IN ADOLESCENTS AND ADULTS
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The aim of the present research was to explore the sex differences that characterize PTSD by means of this experimental paradigm, as well as to offer a preliminary description of how these sex differences behave throughout development.
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