Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat

@article{DAversa2004ExpressionOC,
  title={Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat},
  author={Teresa G. D’Aversa and Karl O. A. Yu and Joan W Berman},
  journal={Journal of NeuroVirology},
  year={2004},
  volume={10},
  pages={86-97}
}
Chemokines are important mediators of inflammation. It has been demonstrated that there is an increase in chemokine expression in both the sera and brain of individuals infected with human immunodeficiency virus type 1 (HIV-1). The HIV-1 viral protein, Tat, a transcriptional regulator, has been detected in the central nervous system (CNS) of infected individuals, and has been demonstrated to induce chemokines from various cells within the brain. The authors now show that the interaction of… CONTINUE READING
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