Expression of chemokine genes in human dermal microvascular endothelial cell lines infected with Orientia tsutsugamushi.

@article{Cho2001ExpressionOC,
  title={Expression of chemokine genes in human dermal microvascular endothelial cell lines infected with Orientia tsutsugamushi.},
  author={Namhoon Cho and Seung Yong Seong and M. S. Choi and In Seop Kim},
  journal={Infection and immunity},
  year={2001},
  volume={69 3},
  pages={1265-72}
}
Scrub typhus, caused by Orientia tsutsugamushi, is characterized by local as well as systemic inflammatory manifestations. The main pathologic change is focal or disseminated multiorgan vasculitis, which is caused by the destruction of endothelial cells and perivascular infiltration of leukocytes. We investigated the regulation of chemokine induction in transformed human dermal microvascular endothelial cells (HMEC-1) in response to O. tsutsugamushi infection. The monocyte chemoattractant… CONTINUE READING