Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts.

@article{Fairchild1997ExpressionOC,
  title={Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts.},
  author={R. L. Heckaman Mark D. Fairchild and Anne M Vanbuskirk and Takashi Kondo and M E Wakely and Charles G. Orosz},
  journal={Transplantation},
  year={1997},
  volume={63 12},
  pages={1807-12}
}
Chemokines are cytokines with chemoattractant properties for leukocytes. They may play a critical role in directing leukocytes to graft sites and in amplifying intragraft inflammation during rejection. Previous studies have tested the intragraft expression of chemokine genes during the rejection of allogeneic skin grafts in mice. In the current study, we used a heterotopic heart transplant model in mice to test the intragraft expression of these genes in nonrejecting cardiac isografts… CONTINUE READING

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