Expression of cell surface P-glycoprotein by an Adriamycin-resistant murine fibrosarcoma

Abstract

Analysis of the cell membrane of Adriamycin (doxorubicin)-resistant UV-2237 ADMR murine fibrosarcoma cells revealed a 170,000-dalton component that is not found in the drug-sensitive parent or revertant cells. Immunoblot (Western blot) analysis showed that this component is similar to the 170,000-dalton P-glycoprotein found on the surface of Chinese hamster… (More)
DOI: 10.1007/BF00257134

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