Expression of cell cycle-related gene products in Langerhans cell histiocytosis.

  title={Expression of cell cycle-related gene products in Langerhans cell histiocytosis.},
  author={Bart Schouten and R Maarten Egeler and Pieter Johannes Maria Leenen and Antonie H M Taminiau and Lambert J J C M van den Broek and P. C. W. Hogendoorn},
  journal={Journal of pediatric hematology/oncology},
  volume={24 9},
BACKGROUND The pathogenesis of Langerhans cell histiocytosis (LCH), a disease characterized by an abnormal accumulation of the dendritic Langerhans cells, is still unknown. Based on the monoclonality of the CD1a+ cell and reports of familial clustering, it is hypothesized that a genetic alteration at a cellular level may be causative. This genetic change may have an effect on the cellular mechanisms controlling proliferation and apoptosis. MATERIALS AND METHODS LCH-lesions were studied for the… CONTINUE READING

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