Expression of cell cycle regulator p27Kip1 is correlated with survival of patients with astrocytoma.

@article{Mizumatsu1999ExpressionOC,
  title={Expression of cell cycle regulator p27Kip1 is correlated with survival of patients with astrocytoma.},
  author={Shinichiro Mizumatsu and Takashi Tamiya and Yuko Ono and Toshihiro Abe and Koichi Matsumoto and Tomohisa Furuta and Takashi Ohmoto},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1999},
  volume={5 3},
  pages={551-7}
}
p27Kip1 is a cyclin-dependent kinase inhibitor that negatively regulates cell proliferation by mediating cell cycle arrest in G1. This study was undertaken to assess the prognostic value of p27Kip1 for astrocytomas. Tissue samples from 130 astrocytomas (WHO grade 1, 5 cases; grade 2, 23 cases; grade 3, 64 cases; grade 4, 38 cases), including 92 primary and 38 recurrent tumors, were examined immunohistochemically for Ki-67 and p27Kip1 expression. Patient charts were reviewed for clinical… CONTINUE READING
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