Expression of cathepsin K in chordoma.

  title={Expression of cathepsin K in chordoma.},
  author={Carsten Haeckel and Sabine Krueger and D{\"o}rthe K{\"u}ster and Helmut Ostertag and Madjid Samii and Frank Buehling and Dieter Br{\"o}mme and Bogdan Czerniak and Albert Roessner},
  journal={Human pathology},
  volume={31 7},
Invasive growth of chordoma is accompanied by severe destruction of adjacent bone tissue, a fact that requires high proteolytic activity at the tumor invasion fronts. In this context, cathepsin K is a candidate molecule. It is a protease with high collagenolytic and elastinolytic activity and previously thought to be restricted to osteoclasts and osteoclast-mediated bone resorption. In this study, 44 cases of chordoma of sphenooccipital localization, and 10 embryo-fetal specimens including… CONTINUE READING