Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion

  title={Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion},
  author={M. Vakkala and P. P{\"a}{\"a}kk{\"o} and Y. Soini},
  journal={British Journal of Cancer},
  pages={592 - 599}
  • M. Vakkala, P. Pääkkö, Y. Soini
  • Published 1999
  • Medicine
  • British Journal of Cancer
  • The aim of this investigation was to study the expression of caspases 3, 6 and 8 and their association to apoptosis in preneoplastic and neoplastic lesions of the breast. The material consisted of nine benign breast epithelial hyperplasias, 15 atypical hyperplasias, 74 in situ and 82 invasive carcinomas. The extent of apoptosis was assessed by the TUNEL method and caspase 3, 6 and 8 expression by immunohistochemistry with specific antibodies. Increased caspase 3 immunopositivity, as compared to… CONTINUE READING
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