Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron.

@article{Tumlin1995ExpressionOC,
  title={Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron.},
  author={James A. Tumlin and J T Someren and Cheryl E. Swanson and Janice P. Lea},
  journal={The American journal of physiology},
  year={1995},
  volume={269 4 Pt 2},
  pages={F558-63}
}
Calcineurin activity and alpha-subunit expression were studied in microdissected proximal tubules (S2), medullary thick ascending limbs (MTAL), cortical collecting ducts (CCD), connecting tubules (CNT), and outer medullary collecting ducts (OMCD). We have shown that cyclosporin A (CsA) and FK-506 inhibit sodium-potassium-adenosinetriphosphatase (Na-K-ATPase) activity in CCD, OMCD, and MTAL but did not uncover the mechanism for resistance of proximal tubule segments to these drugs. Because cells… CONTINUE READING