Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.

@article{Ho1996ExpressionOC,
  title={Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.},
  author={Brian Kong Wai Ho and Maria E Alexianu and Luis V. Colom and Amira Hamed Mohamed and Fernando Serrano and Stanley H. Appel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 13},
  pages={6796-801}
}
Calbindin-D28K and/or parvalbumin appear to influence the selective vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS). Their immunoreactivity is undetectable in motoneurons readily damaged in human ALS, and in differentiated motoneuron hybrid cells [ventral spinal cord (VSC 4.1 cells)] that undergo calcium-dependent apoptotic cell death in the presence of ALS immunoglobulins. To provide additional evidence for the role of calcium-binding proteins in motoneuron vulnerability… CONTINUE READING

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