• Corpus ID: 12739804

Expression of c-myc in human colonic tissue in response to beta-carotene supplementation.

@article{Gowda1997ExpressionOC,
  title={Expression of c-myc in human colonic tissue in response to beta-carotene supplementation.},
  author={B Gowda and J Qin and Sohrab Mobarhan and Thomas O. Frommel},
  journal={Nutrition and cancer},
  year={1997},
  volume={28 2},
  pages={
          135-9
        }
}
Dietary supplementation with beta-carotene at 30 mg/day results in an increased serum trans-retinoic acid concentration in patients with a prior colonic polyp. In a number of human cell lines, trans-retinoic acid upregulates c-myc mRNA expression in colonic mucosa by reverse transcription polymerase chain reaction and correlated the results with serum concentrations of all-trans- (ATRA), 13-cis-(13-cRA), and total retinoic acid. Serum and colonic biopsy samples were obtained before and 90 days…