Expression of c-kit receptor in normal and transformed human nonlymphoid tissues.

@article{Natali1992ExpressionOC,
  title={Expression of c-kit receptor in normal and transformed human nonlymphoid tissues.},
  author={Pier Giorgio Natali and Maria Rita Nicotra and Irmi Sures and Eugenio Santoro and Aldo Bigotti and Axel Ullrich},
  journal={Cancer research},
  year={1992},
  volume={52 22},
  pages={6139-43}
}
The protooncogene c-kit encodes a tyrosine kinase with a molecular weight of 145,000, highly related to the platelet derived growth factor/colony stimulating factor receptors. Mutations of the murine gene result in impairment of hematopoiesis, gametogenesis, and of the melanocyte cell lineage. In order to elucidate c-kit functions in development and oncogenesis we have analyzed immunohistochemically its expression in human normal and transformed nonlymphoid tissues. The receptor has been… CONTINUE READING
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