Expression of c‐myc in human colonic tissue in response to β‐carotene supplementation

  title={Expression of c‐myc in human colonic tissue in response to $\beta$‐carotene supplementation},
  author={B Gowda and J Qin and Sohrab Mobarhan and Thomas O. Frommel},
  journal={Nutrition and Cancer},
Abstract Dietary supplementation with β‐carotene at 30 mg/day results in an increased serum trans‐retinoic acid concentration in patients with a prior colonic polyp. In a number of human cell lines, trans‐retinoic acid upregulates c‐myc mRNA expression. We assayed for changes in c‐myc mRNA expression in colonic mucosa by reverse transcription polymerase chain reaction and correlated the results with serum concentrations of all‐trans‐ (ATRA), 75‐cis‐ (13‐cRA), and total retinoic acid. Serum and… 
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