Expression of brain-derived neurotrophic factor in the central nervous system of mice using a poliovirus-based vector

@article{Jia2002ExpressionOB,
  title={Expression of brain-derived neurotrophic factor in the central nervous system of mice using a poliovirus-based vector},
  author={Qingmei Jia and Fengyi Liang and Seii Ohka and A. Nomoto and Tsutomu Hashikawa},
  journal={Journal of NeuroVirology},
  year={2002},
  volume={8},
  pages={14-23}
}
Brain-derived neurotrophic factor (BDNF) is a promising candidate for the gene therapy of neurological disease. To deliver BDNF to neurons of the central nervous system (CNS), a nucleotide sequence encoding the mature peptide of BDNF was inserted into the genome of poliovirus, a neurotropic virus that is known to replicate mainly in motor neurons of the… CONTINUE READING