Corpus ID: 22447261

Expression of both alpha 1- and alpha 2-adrenoceptors in an insulin-secreting cell line. Parallel studies of cytosolic free Ca2+ and insulin release.

@article{Ullrich1985ExpressionOB,
  title={Expression of both alpha 1- and alpha 2-adrenoceptors in an insulin-secreting cell line. Parallel studies of cytosolic free Ca2+ and insulin release.},
  author={S. Ullrich and C. Wollheim},
  journal={Molecular pharmacology},
  year={1985},
  volume={28 2},
  pages={
          100-6
        }
}

S. Ullrich, C. Wollheim

Published 1985

Chemistry, Medicine

Molecular pharmacology

Changes in intracellular free Ca2+, [Ca2+]i, and immunoreactive insulin release in response to alpha-adrenergic agents were measured in RINm5F cell suspensions. Cells were loaded with the fluorescent indicator quin 2 for monitoring [Ca2+]i. Epinephrine (1 microM), which inhibited alanine-stimulated insulin release by 73%, evoked a transient rise in [Ca2+]i. This rise is in part due to Ca2+ mobilization, since it is still present in the absence of extracellular Ca2+. The alpha 2-adrenergic… CONTINUE READING

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