Expression of bone morphogenetic proteins in salivary pleomorphic adenomas

  title={Expression of bone morphogenetic proteins in salivary pleomorphic adenomas},
  author={Kimihide Kusafuka and Akira Yamaguchi and Teruo Kayano and Mutsunori Fujiwara and Tamiko Takemura},
  journal={Virchows Archiv},
 Salivary pleomorphic adenomas are often associated with chondroid tissue formation. We investigated the relationship between chondroid tissue formation and the expression of bone morphogenetic proteins (BMPs), which are strong inducers of ectopic bone and cartilage formation. Fifteen pleomorphic adenomas and seven normal salivary glands were examined genetically and immunohistochemically. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that BMP-1, BMP… CONTINUE READING
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