Expression of bone matrix proteins mRNA during distraction osteogenesis.

  title={Expression of bone matrix proteins mRNA during distraction osteogenesis.},
  author={Masahiro Sato and Natsuo Yasui and Takanobu Nakase and Hirohisa Kawahata and Mizuo Sugimoto and Seiichi Hirota and Yukihiko Kitamura and Shintaro Nomura and Takahiro Ochi},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={13 8},
Distraction osteogenesis is a recently advanced principle of bone lengthening in which a bone separated by osteotomy is subjected to slow progressive distraction using an external fixation device. Appropriate mechanical tension-stress is believed not to break the callus but rather to stimulate osteogenesis. To study the molecular features of this process, the expression and localization of the mRNAs encoding osteopontin (OPN), osteocalcin (OC), matrix Gla protein (MGP), osteonectin (ON), and… CONTINUE READING


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