Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas.

@article{Ibrahim1999ExpressionOB,
  title={Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas.},
  author={Salah Osman Ibrahim and Johan Rikard Lillehaug and Anne Christine Johannessen and Per Gunnar Liavaag and Rita Nilsen and Endre Normann Vasstrand},
  journal={Oral oncology},
  year={1999},
  volume={35 3},
  pages={302-13}
}
Using immunohistochemistry, expression of p53, transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGFR), c-erbB-2/neu and proliferating cell nuclear antigen (PCNA) was examined in 26 fresh frozen tissue specimens of oropharyngeal squamous cell carcinomas (SCCs). p53 gene mutations were examined by polymerase chain reaction (PCR)/DNA sequencing methods in 22 carcinomas. The findings were examined for correlations with patients' clinicopathological parameters… CONTINUE READING
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