Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis.

@article{Dourado1996ExpressionOB,
  title={Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis.},
  author={Gilvan Dourado and Mark E. Adams and John R Matyas and Dingqiu Huang},
  journal={Osteoarthritis and cartilage},
  year={1996},
  volume={4 3},
  pages={
          187-96
        }
}
This study sought to assess the relative levels of the mRNAs of the core proteins of the small proteoglycans (PGs) biglycan, decorin and fibromodulin in the hypertrophic phase of the early osteoarthritis (OA) that follows joint injury. Experimental OA was induced in eight dogs by transection of the anterior cruciate ligament. Articular cartilage was harvested from each joint, the total RNA was extracted and the concentration of DNA in the cartilage was measured. The relative levels of mRNA for… CONTINUE READING