Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

@article{Ungerer1994ExpressionOB,
  title={Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.},
  author={Martin Ungerer and G Parruti and Michael B{\"o}hm and Mechthild Puzicha and A Deblasi and Erland Erdmann and Martin J. Lohse},
  journal={Circulation research},
  year={1994},
  volume={74 2},
  pages={206-13}
}
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase in beta-adrenergic receptor kinase (beta ARK) expression. beta ARK is thought to effect desensitization by acting in concert with an inhibitor protein, called beta-arrestin. Two isoforms have been identified both for beta ARK and for beta-arrestin. In the present study, we have investigated the expression of the… CONTINUE READING

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