Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes

  title={Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes},
  author={Josephine C. Adams and Fiona M Watt},
  journal={The Journal of Cell Biology},
  pages={829 - 841}
We have compared the adhesive properties and integrin expression profiles of cultured human epidermal keratinocytes and a strain of nondifferentiating keratinocytes (ndk). Both cell types adhered to fibronectin, laminin, and collagen types I and IV, but ndk adhered more rapidly and at lower coating concentrations of the proteins. Antibody blocking experiments showed that adhesion of both cell types to fibronectin was mediated by the alpha 5 beta 1 integrin and to laminin by alpha 3 beta 1 in… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 56 references

The role of integrins a2ß, and 01301 in cell-cell and cell-substrate adhesion of human epidermal cells

Carter, G W., E . A . Wayner, T . S . Bouchard, P . Kaur
EMBO (Eur. Mol. Biol. Organ.) J • 1990
View 4 Excerpts
Highly Influenced

Decreased expression of fibronectin and the a 5 ß , integrin during terminal differentiation of human keratinocytes

J. Peltonen, H. Larjava, +5 authors J. Uitto
J . Cell Sci . • 1991

Integri n expression during human epidermal development in vivo and in vitro

D. Lewis, K. McNulty
Development . • 1991

Polarized expression of integrin receptors ( a 6 Ó 4 , a 2 ß , , a 3 ß , , and avP and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes

R. Timpl, K. Kuhn
J . Cell Biol . • 1991

Activation ofhuman keratinocyte migration on type I collagen and fibronectin

L. F. Reichardt, E. Crowley, B. Holley, H. Moezzi
J . Cell Sci . • 1990

Changes in keratinocyte - extracellular matrix interactions during terminal differentiation : reduction in fibronectin binding precedes loss of the a 5 ß , integrin from the cell surface

S. S. Yamada, W.-T. Chen, K. M. Yamada

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