Expression of bcl-2 mRNA and protein in leukemia-lymphoma cell lines.

  title={Expression of bcl-2 mRNA and protein in leukemia-lymphoma cell lines.},
  author={Klaus G. Steube and A Jadau and D Teepe and H. G. Drexler},
  volume={9 11},
The expression of the proto-oncogene bcl-2 was examined in a panel of 75 continuous human leukemia-lymphoma cell lines originated from different hematopoietic cell types. The presence of the bcl-2 protein, as evidenced by Western blotting, and its mRNA, as determined by Northern blotting, were not restricted to cells with the chromosomal translocation t(14;18)(q32;q21), but were also detected in a large number of cell lines without t(14;18). The amount of the bcl-2 protein and mRNA in the cell… CONTINUE READING
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