Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia.

@article{Linnik1995ExpressionOB,
  title={Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia.},
  author={Matthew D. Linnik and Peter Zahos and Michael D. Geschwind and Howard J. Federoff},
  journal={Stroke},
  year={1995},
  volume={26 9},
  pages={1670-4; discussion 1675}
}
BACKGROUND AND PURPOSE A process resembling programmed cell death appears to contribute to postischemic neuronal loss in several models of stroke. Because the expression of the bcl-2 gene has been shown to rescue neurons from programmed cell death due to other causes, we determined whether it would be similarly neuroprotective in stroke. METHODS Replication of defective herpes viral vectors that transduce bcl-2 (HSVbcl2) or Escherichia coli lacZ (HSVlac) were injected into two sites in the… CONTINUE READING

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