Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.

@article{Rusyn2004ExpressionOB,
  title={Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.},
  author={Ivan Rusyn and Shoji Asakura and Brian F Pachkowski and Blair U. Bradford and Mikhail F. Denissenko and Jeffrey M. Peters and Steven M Holland and Janardan K. Reddy and Michael L. Cunningham and James A. Swenberg},
  journal={Cancer research},
  year={2004},
  volume={64 3},
  pages={1050-7}
}
Oxidative stress to DNA is recognized as one of the mechanisms for the carcinogenic effects of some environmental agents. Numerous studies have been conducted in an attempt to document the fact that chemical carcinogens that are thought to induce production of oxidants also cause the formation of oxidative DNA lesions. Although many DNA adducts continue to be useful biomarkers of dose/effect, changes in gene expression have been proposed to be a practical novel tool for studying the role of… CONTINUE READING