Expression of atrial myosin light chains but not α-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy

@article{Ritter1999ExpressionOA,
  title={Expression of atrial myosin light chains but not α-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy},
  author={Oliver Ritter and Hans Peter Luther and Hannelore Haase and Leonidas G. Baltas and Gert Baumann and Hagen Dieter Schulte and Ingo Morano},
  journal={Journal of Molecular Medicine},
  year={1999},
  volume={77},
  pages={677-685}
}
The adult rodent heart adapts to increased work load by reexpression of its fetal genes, for example, β-myosin heavy chain (MHC), in order to improve contractile function. However, the human ventricle regulates contractility by expression of atrial essential myosin light chain (ALC-1) rather than β-MHC. We evaluated the impact of both mechanisms in patients with hypertrophic cardiomyopathy. MHC isoform expression was quantified at the mRNA and protein levels by reverse transcriptase polymerase… CONTINUE READING

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