Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure

@article{Thumburu2014ExpressionOA,
  title={Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure},
  author={Kiran Kumar Thumburu and Radha K. Dhiman and Rakesh kumar Vasishta and Anuradha Chakraborti and Roger F. Butterworth and {\'E}lizabeth Beauchesne and Paul Desjardins and Sandeep Goyal and Navneet Sharma and Ajay K. Duseja and Yogesh K. Chawla},
  journal={Journal of Neurochemistry},
  year={2014},
  volume={128},
  pages={617 - 627}
}
In vitro and in vivo studies have suggested that reduced astrocytic uptake of neuronally released glutamate, alterations in expression of glial fibrillary acidic protein (GFAP) and aquaporin‐4 (AQP‐4) contribute to brain edema in acute liver failure (ALF). However, there is no evidence to date to suggest that these alterations occur in patients with ALF. We analyzed the mRNA expression of excitatory amino acid transporters (EAAT‐1, EAAT‐2), GFAP, and AQP‐4 in the cerebral cortex obtained at… Expand
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