Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines.

@article{Smallwood2014ExpressionOA,
  title={Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines.},
  author={Tangi L. Smallwood and George W. Small and Steven E. Suter and Kristy L Richards},
  journal={Leukemia & lymphoma},
  year={2014},
  volume={55 6},
  pages={1357-65}
}
l-asparaginase (L-asp), a bacterial enzyme that depletes extracellular asparagine, is used to treat acute lymphoblastic leukemia in humans and a variety of aggressive lymphoid malignancies in dogs. Resistance to this drug is an important cause of treatment failure in both species. Using canine lymphoid cell lines, we found that L-asp sensitivity is strongly… CONTINUE READING