Expression of argininosuccinate synthetase in patients with hepatocellular carcinoma.


BACKGROUND AND AIM Arginine is a nonessential amino acid for humans and mice because it can be synthesized from citrulline by argininosuccinate synthetase (ASS) and argininosuccinate lyase. Hepatocellular carcinoma (HCC) is believed to be auxotrophic for arginine through the lack of expression of ASS. However, there are also some ASS-positive HCC cells… (More)
DOI: 10.1111/jgh.12043


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