Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice.

@article{Crittenden2014ExpressionOA,
  title={Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice.},
  author={Marka R. Crittenden and Talicia Savage and Benjamin L Cottam and Jason R. Baird and P Cabanas Rodr{\'i}guez and Pippa Newell and Kristina H Young and Andrew Michael Jackson and Michael J Gough},
  journal={Radiation research},
  year={2014},
  volume={182 2},
  pages={182-90}
}
An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune responses that contribute to tumor control. However, in the absence of additional immune therapy, the adaptive immune response is insufficient to prevent tumor recurrence or affect distant disease. It has been shown in multiple models that tumor-infiltrating myeloid cells exhibit alternative activation phenotypes and are able to suppress adaptive immune responses, and recent data suggests that the… CONTINUE READING
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