Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys.

@article{Ortiz1997ExpressionOA,
  title={Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys.},
  author={Alberto Ortiz and Fuad N. Ziyadeh and Eric G. Neilson},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={1997},
  volume={45 2},
  pages={50-6}
}
BACKGROUND Members of the bcl-2 family of proteins regulate the occurrence of apoptotic cell death. Apoptosis is a feature of both acute and chronic renal diseases. Diabetes mellitus modulates renal growth; it induces acute tubuloepithelial cell hypertrophy, leads to chronic glomerulopathy associated with tubular epithelial cell atrophy and interstitial fibrosis, and predisposes to renal cell loss from acute nephrotoxic injury. However, the mechanisms by which diabetes affects renal cell… CONTINUE READING