Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues.

@article{Masumoto2001ExpressionOA,
  title={Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues.},
  author={Junya Masumoto and Shun'ichiro Taniguchi and Jun Nakayama and Masaaki Shiohara and Eiko Hidaka and T. Katsuyama and Shin Murase and Junji Sagara},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2001},
  volume={49 10},
  pages={1269-75}
}
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is a pyrin N-terminal homology domain (PYD)- and caspase recruitment domain (CARD)-containing a proapoptotic molecule. This molecule has also been identified as a target of methylation-induced silencing (TMS)-1. We cloned the ASC cDNA by immunoscreening using an anti-ASC monoclonal antibody. In this study, we determined the binding site of the anti-ASC monoclonal antibody on ASC and analyzed the expression of… CONTINUE READING