Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin

@article{Jena2011ExpressionOA,
  title={Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin},
  author={Srikanta Jena and Gagan Bihari Nityananda Chainy and Jagneshwar Dandapat},
  journal={Molecular Biology Reports},
  year={2011},
  volume={39},
  pages={1193-1203}
}
The present study was undertaken to investigate the effect of vitamin E and curcumin on the expression of antioxidant genes in 6-propyl-2-thiouracil (PTU)-induced hypothyroid rat renal cortex. The levels of lipid peroxidation and protein carbonylation were increased in hypothyroid rat kidney. Co-administration of vitamin E and curcumin to hypothyroid rats resulted in amelioration of lipid peroxidation level, whereas curcumin alone alleviated the protein carbonylation level. The mRNA levels of… CONTINUE READING
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