Expression of antigens related to apoptosis and cell proliferation in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis

@article{Kuroki1996ExpressionOA,
  title={Expression of antigens related to apoptosis and cell proliferation in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis},
  author={Tetsuo Kuroki and Shuichi Seki and Nobuyoshi Kawakita and Kazuki Nakatani and Takuya Kitada and Hiroki Sakaguchi and Tomoyuki Hisa},
  journal={Virchows Archiv},
  year={1996},
  volume={429},
  pages={119-129}
}
The initial injury in primary biliary cirrhosis (PBC) is the destruction of portal bile ducts. Little information is available on apoptosis and cell proliferation in such bile ducts, so we used immunohistochemical techniques to locate molecules related to apoptosis [Fas antigen, Lewis Y antigen (BM1/JIMRO), and bcl-2 protein] and to cell proliferation (proliferating cell nuclear antigen, PCNA) in 21 patients with PBC. In addition, nick-end labelling was done to locate DNA fragmentation. The… CONTINUE READING
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