Expression of anoctamins in retinal pigment epithelium (RPE)

  title={Expression of anoctamins in retinal pigment epithelium (RPE)},
  author={Rainer Schreiber and Karl Kunzelmann},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
The anoctamin (ANO, TMEM16) family of Ca2+-activated Cl− channels consists of ten members with different cellular functions (ANO1–10). ANO1 is a Ca2+-activated Cl− channel in secretory epithelial cells of exocrine pancreas, salivary glands, or enterocytes. Expression of ANO1 also promotes cell proliferation and migration of tumor cells. ANO6 is essential for Ca2+-dependent scrambling of membrane phospholipids in platelets, red blood cells, and lymphocytes. ANO10 modulates Ca2+ signals in… CONTINUE READING
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