Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome

@article{Zimmermann2004ExpressionOA,
  title={Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome},
  author={Uwe Zimmermann and Christian Woenckhaus and Stefan Pietschmann and Heike P Junker and Sergei Maile and K. Schultz and Chris Protzel and J{\"u}rgen Giebel},
  journal={Virchows Archiv},
  year={2004},
  volume={445},
  pages={368-374}
}
Conventional renal cell carcinomas (CRCCs) were investigated for the expression of annexin II (ANX II) to determine out whether this calcium-binding protein could serve as a useful prognostic marker. CRCCs and adjacent nonneoplastic tissue from 33 patients were investigated for ANX II by immunohistochemistry, RT-PCR, and western blot analysis. ANX II expression was correlated with tumor differentiation (Fuhrman grade) and to clinical outcome. Tumors were composed of ANX II positive and negative… CONTINUE READING

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