Expression of angiotensin II type 1 (AT(1)) receptor in the rostral ventrolateral medulla in rats.

@article{Hu2002ExpressionOA,
  title={Expression of angiotensin II type 1 (AT(1)) receptor in the rostral ventrolateral medulla in rats.},
  author={Lian Hu and Da-nian Zhu and Zhang Yu and John Q. Wang and Zhongyuan Sun and Tai Yao},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 5},
  pages={
          2153-61
        }
}
In the present study, the changes of amino acids release in the spinal cord after the application of angiotensin II (ANG II) in the rostral ventrolateral medulla (RVLM) and the distribution of ANG receptors on neurons of the RVLM were investigated. A microdialysis experiment showed that microinjection of angiotensin II into the RVLM significantly (P < 0.01) increased the release of aspartate and glutamate in the intermediolateral column of the spinal cord. Immunofluorescence technique combined… 
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TLDR
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TLDR
Results indicate that AT2Rs are present on the RVLM neurons projecting to the IML and their blockade results in sympathoexcitatory responses, which may play a role in genesis and/or maintenance of hypertension in SHR.
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Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension
TLDR
It is concluded that Ang II modulates the pressor effect through AT1R-dependent ROS-SAPK/JNK signaling in glutamatergic neurons in the RVLM of SIHR.
AT1 receptor in rostral ventrolateral medulla mediating blunted baroreceptor reflex in spontaneously hypertensive rats.
TLDR
Blockage of At1 receptor or inhibition of AT1 receptor protein synthesis in the RVLM enhanced the BRS in SHR, suggesting that the enhanced activities of AT2 receptor in the RVLM contribute to the blunted BRSIn SHR.
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References

SHOWING 1-10 OF 55 REFERENCES
Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit
Central Amino Acids Mediate Cardiovascular Response to Angiotensin II in the Rat
Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II.
TLDR
The present data suggest that ANG II endogenous to RVLM and CVLM acts as a tonic excitatory agent on vasomotor neurons of the VLM.
Evidence that angiotensin-(1–7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors
Losartan, nonpeptide angiotensin II-type 1 (AT1) receptor antagonist, attenuates pressor and sympathoexcitatory responses evoked by angiotensin II andL-glutamate in rostral ventrolateral medulla
Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain.
TLDR
Their differential localization and development suggest different functions for the specific angiotensin II receptor sub types, which may be involved in control and learning of motor activity, sensory areas, and selected limbic system structures.
Localization of angiotensin II AT1 receptor-like immunoreactivity in catecholaminergic neurons of the rat medulla oblongata
AT(1) receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus.
TLDR
Results indicate that excitatory synaptic inputs to pressor neurons in the rostral ventrolateral medulla arising from activation of the paraventricular nucleus are mediated predominantly by AT(1) receptors.
Role of AT1 receptors in the central control of sympathetic vasomotor function.
  • G. Head
  • Biology
    Clinical and experimental pharmacology & physiology. Supplement
  • 1996
TLDR
The present review describes studies in which the contribution of angiotensin receptors in the brainstem to cardiovascular regulation, in particular sympathetic vasomotor reflexes, has been examined in conscious and anaesthetized rabbits, and suggests that the RVLM is a likely candidate site for the modulation of the renal sympathetic baroreflex.
Tonic cardiovascular effects of angiotensin II in the ventrolateral medulla.
TLDR
Results indicate that endogenous angiotensin II acts on specific receptors within the rostral and caudal parts of the ventrolateral medulla and has a tonic excitatory action on sympathoexcitatory and sympathoinhibitory neurons within these respective regions.
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