Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension.

Abstract

Angiotensin II receptor-like 1 (APJ), a G protein-coupled receptor that was identified as a homologue of angiotensin II type 1 (AT1) receptor, exerts antagonistic effects on AT1-mediated vasoconstriction. Studies on pregnancy-induced hypertension (PIH) revealed aberrant activation of AT1 downstream signaling. In contrast, little is known about APJ in the… (More)
DOI: 10.1097/PGP.0b013e31823b6e71

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