Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation.

@article{Krikun2000ExpressionOA,
  title={Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation.},
  author={Graciela Krikun and Frederick Schatz and T. A. Finlay and Susan S Kadner and Augusto F Mesia and Ren{\'e} Gerrets and Charles Joseph Lockwood},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={275 1},
  pages={159-63}
}
The functional endometrial layer receives the implanting blastocyst, but is sloughed off during menstruation. Angiogenesis regulates growth and repair of cycling human endometrium. While vascular endothelial growth factor initiates angiogenesis, the angiopoietins (Angs) acting via the Tie2 receptor, are key regulators of subsequent angiogenic steps. This study is the first to localize Ang-2 and Tie2 in human endometrium and to study Ang-2 regulation in cultured human endometrial endothelial… CONTINUE READING
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