Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1.

@article{BobrovnikovaMarjon2004ExpressionOA,
  title={Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1.},
  author={Ekaterina V. Bobrovnikova-Marjon and Philip L. Marjon and Olena Barbash and David L. Vander Jagt and Steven F. Abcouwer},
  journal={Cancer research},
  year={2004},
  volume={64 14},
  pages={4858-69}
}
Vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8) are prominent pro-angiogenic and pro-metastatic proteins that represent negative prognostic factors in many types of cancer. Hypoxia is thought to be the primary environmental cause of VEGF and IL-8 expression in solid tumors. We hypothesized that a lack of nutrients other than oxygen could stimulate the expression of these factors and previously demonstrated that expression of VEGF and IL-8 is responsive to amino acid… CONTINUE READING

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