Expression of an outwardly rectifying K+ channel in rat microglia cultivated on teflon.

@article{Nrenberg1993ExpressionOA,
  title={Expression of an outwardly rectifying K+ channel in rat microglia cultivated on teflon.},
  author={Wolfgang N{\"o}renberg and Kurt Appel and Jan Niklas Bauer and Peter J. Gebicke-Haerter and P{\'e}ter Ill{\'e}s},
  journal={Neuroscience letters},
  year={1993},
  volume={160 1},
  pages={69-72}
}
Membrane currents of cultured human monocytes and rat microglia were recorded with the whole-cell patch clamp technique. Freshly isolated monocytes or resting (proliferating) microglia express only inwardly rectifying K+ channels. However, incubation in teflon bags leads to the expression of additional, outwardly rectifying K+ channels. The outward K+ conductance of microglial cells was inhibited by intracellular Cs+ and extracellular 4-aminopyridine or tetraethylammonium. Functional… CONTINUE READING