Expression of an endogenous retroviral transcript is associated with murine lupus.

@article{Krieg1989ExpressionOA,
  title={Expression of an endogenous retroviral transcript is associated with murine lupus.},
  author={Arthur M. Krieg and Arifa S. Khan and Alfred D. Steinberg},
  journal={Arthritis and rheumatism},
  year={1989},
  volume={32 3},
  pages={
          322-9
        }
}
  • Arthur M. Krieg, Arifa S. Khan, Alfred D. Steinberg
  • Published in Arthritis and rheumatism 1989
  • Medicine, Biology
  • We have been investigating whether murine lupus is associated with endogenous type C retroviral expression. We used Northern blot analyses and oligonucleotide probes, which are able to distinguish the envelope genes of the xenotropic and mink cell focus-forming (MCF) classes of type C retroviruses. Xenotropic expression in the spleen varied markedly among inbred mouse strains; although all strains expressed a 1.8-kb transcript, only one-half expressed one or more larger transcripts (8.4, 7.2… CONTINUE READING

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